"The potential of conolidine instead pain management Answer is critical, specifically in the context in the opioid crisis." In knee pain, nerves throughout the joint could become sensitized and possess an elevated notion of pain. The consequences of conolidine around the opioid scavenger receptor can indirectly desensitize these nerves. https://www.proleviate.com/post/how-does-conolidine-treat-knee-pain