You will find a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to minimize afferent pain transmission and make analgesia. Consequently, medication like clonidine that concentrate on alpha-two receptors can impact the transmission of ache. Could be given as monotherapy https://robertn790omj6.wikicorrespondence.com/user