Opioid activity is because of both reduced affinity binding in the parent compound and better affinity binding of the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is nearly six occasions far more strong than tramadol in generating analgesia and 200 instances a lot more strong in μ-opioid https://adolfe036zhn9.wikikali.com/user